TY - JOUR
T1 - Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo
AU - Daniels, Dianne
AU - Sharabi, Shirley
AU - Last, David
AU - Guez, David
AU - Salomon, Sharona
AU - Zivli, Zion
AU - Castel, David
AU - Volovick, Alex
AU - Grinfeld, Javier
AU - Rachmilevich, Itay
AU - Amar, Talia
AU - Liraz-Zaltsman, Sigal
AU - Sargsyan, Narek
AU - Mardor, Yael
AU - Harnof, Sagi
N1 - Publisher Copyright:
© 2018 World Federation for Ultrasound in Medicine and Biology
PY - 2018/5
Y1 - 2018/5
N2 - The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.
AB - The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.
KW - Auditory evoked potentials
KW - Focused ultrasound
KW - Neuromodulation
UR - http://www.scopus.com/inward/record.url?scp=85042629372&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2018.01.010
DO - 10.1016/j.ultrasmedbio.2018.01.010
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C2 - 29501283
AN - SCOPUS:85042629372
SN - 0301-5629
VL - 44
SP - 1022
EP - 1030
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 5
ER -