Focal segmental glomerulosclerosis. With proteinuria and chronic interstitial nephritis

Four children are described who presented heavy proteinuria and in whom radiologic evaluation showed bilateral VUR (vesicoureteral reflux) with either hydronephrotic or contracted kidneys. They had histologic findings similar to those of focal segmental glomerulosclerosis in addition to those of CIN (chronic interstitial nephritis). In spite of correction of the urologic abnormality, heavy proteinuria and deterioration of kidney function continued. The authors feel that this evolution may be secondary to the glomerular lesion.