Focal lymphocytic infiltration in aging human palatal salivary glands: A comparative study with labial salivary glands

Marilena Vered, Amos Buchner, Elena Haimovici, Yehuda Hiss, Dan Dayan

Research output: Contribution to journalArticlepeer-review

Abstract

Investigation of age-related prevalence of various types of focal lymphocytic infiltration (FLI) and degrees of histomorphologic changes was conducted on 120 biopsies of palatal and labial salivary glands (PSG and LSG, respectively) obtained from autopsy subjects free of salivary gland tumors/diseases. Biopsies were divided into young (<30 years, n=30), adult (30-60 years, n=45) and old (>60 years, n=45) age groups. A modified Chisholm & Mason grading system was used to record grades of FLI and a modified Greenspan et al. system was used to evaluate the severity of histomorphologic changes. The prevalence of FLI in PSG increased significantly from 10% in the young group to 46.6% in the old group (P=0.0012). No significant changes were found with aging in LSG. FLI was significantly more prevalent in the adult and old age groups in PSG as compared with LSG (P=0.015 and P=0.003, respectively). Both glands demonstrated significant histomorphologic changes among age groups (p<0.0001); however, these changes were significantly less common in the old age group in PSG as compared to LSG (P=0.003). In cases showing severe histomorphologic changes, FLI was not present. Therefore, FLI should not be considered as part of the deteriorating histomorphologic changes that are usually encountered in salivary glands with aging. The immunologic profile of these infiltrates should be further clarified to understand their role, both in physiologic and pathologic conditions.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume30
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Aging
  • Focal lymphocytic infiltration
  • Labial salivary glands
  • Palatal salivary glands

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