Focal Epilepsy in Individuals with Laron Syndrome

Lotem Goldberg, Zvi Laron, Liora Kornreich, Oded Scheuerman, Hadassa Goldberg-Stern, Dror Kraus*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalHormone Research in Paediatrics
Issue number3
StatePublished - 1 Aug 2022


  • Epilepsy
  • Insulin-like growth factor-1
  • Laron syndrome
  • Seizures


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