Focal Epilepsy in Individuals with Laron Syndrome

Lotem Goldberg; Zvi Laron; Liora Kornreich; Oded Scheuerman; Hadassa Goldberg-Stern; Dror Kraus

doi:10.1159/000524350

Focal Epilepsy in Individuals with Laron Syndrome

Lotem Goldberg, Zvi Laron, Liora Kornreich, Oded Scheuerman, Hadassa Goldberg-Stern, Dror Kraus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

Original language	English
Pages (from-to)	286-290
Number of pages	5
Journal	Hormone Research in Paediatrics
Volume	95
Issue number	3
DOIs	https://doi.org/10.1159/000524350
State	Published - 1 Aug 2022

Keywords

Epilepsy
Insulin-like growth factor-1
Laron syndrome
Seizures

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title = "Focal Epilepsy in Individuals with Laron Syndrome",

abstract = "Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.",

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T1 - Focal Epilepsy in Individuals with Laron Syndrome

AU - Goldberg, Lotem

AU - Laron, Zvi

AU - Kornreich, Liora

AU - Scheuerman, Oded

AU - Goldberg-Stern, Hadassa

AU - Kraus, Dror

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

AB - Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

KW - Epilepsy

KW - Insulin-like growth factor-1

KW - Laron syndrome

KW - Seizures

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Focal Epilepsy in Individuals with Laron Syndrome

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