Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.
- Insulin-like growth factor-1
- Laron syndrome