Fmoc-diphenylalanine gelating nanoarchitectonics: A simplistic peptide self-assembly to meet complex applications

Yunxiao Wang, Qiang Geng, Yan Zhang, Lihi Adler-Abramovich*, Xinyuan Fan, Deqing Mei, Ehud Gazit, Kai Tao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), has been has been extensively explored due to its ultrafast self-assembly kinetics, inherent biocompatibility, tunable physicochemical properties, and especially, the capability of forming self-sustained gels under physiological conditions. Consequently, various methodologies to develop Fmoc-FF gels and their corresponding applications in biomedical and industrial fields have been extensively studied. Herein, we systemically summarize the mechanisms underlying Fmoc-FF self-assembly, discuss the preparation methodologies of Fmoc-FF hydrogels, and then deliberate the properties as well as the diverse applications of Fmoc-FF self-assemblies. Finally, the contemporary shortcomings which limit the development of Fmoc-FF self-assembly are raised and the alternative solutions are proposed, along with future research perspectives.

Original languageEnglish
Pages (from-to)113-133
Number of pages21
JournalJournal of Colloid and Interface Science
StatePublished - 15 Apr 2023


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