Flux balance analysis accounting for metabolite dilution

Tomer Benyamini, Ori Folger, Eytan Ruppin, Tomer Shlomi

Research output: Contribution to journalArticlepeer-review

Abstract

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.

Original languageEnglish
Article numberr43
JournalGenome Biology
Volume11
Issue number4
DOIs
StatePublished - 16 Apr 2010

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