Fluorescent photon migration theory for turbid biological media

Amir H. Gandjbakhche, Robert F. Bonner, Israel Gannot, Jay R. Knutson, Reza Navai, Ralph J. Nossal, George H. Weiss

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations

Abstract

Fluorescence imaging in situ may provide highly specific identification of cell types and altered metabolic activity near the surface of tissue. Most approaches to developing the necessary analytical framework for quantitative 3-D use are based on numerical solutions of some form of transport equation. These are highly computer-intensive and can only be carried out for specified parameters. We apply a random walk model for photon migration which enables us to find an exact expression for the frequency-dependent fluorescent signal emitted from the site of a single fluorophore. Our general expression allows for broad variation of the degree of absorptivity, and is potentially important in providing a basis for the development of fluorescence image reconstruction algorithms.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2679
DOIs
StatePublished - 1996
Externally publishedYes
EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy - San Jose, CA, United States
Duration: 29 Jan 199629 Jan 1996

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