TY - JOUR
T1 - Fluorescent in-situ hybridization (FISH) as an aid to marker chromosome identification in prenatal diagnosis
AU - Amiel, A.
AU - Fejgin, M.
AU - Appelman, Z.
AU - Shapiro, I.
AU - Gaber, E.
AU - Bachar, A.
AU - Zamir, R.
AU - Kedar, I.
AU - Golbus, M.
PY - 1995/3
Y1 - 1995/3
N2 - Five cases of supernumerary marker chromosomes were identified in prenatal diagnosis as derived from chromosomes 18, X, and Y. One unexpected finding was in a case where the PCR was positive for the SRY gene while fluorescence in situ hybridization was positive for two X centromeres. In another case with an X derived supernumerary marker the newborn was phenotypically normal. Two women with fetal mar(18) and mar(Xp) decided to terminate the pregnancy. The fifth pregnancy had a karyotype of 46,XX,-15,+der(15)t(Y:15)(q11,23;p13). A phenotypically normal girl was born at term.
AB - Five cases of supernumerary marker chromosomes were identified in prenatal diagnosis as derived from chromosomes 18, X, and Y. One unexpected finding was in a case where the PCR was positive for the SRY gene while fluorescence in situ hybridization was positive for two X centromeres. In another case with an X derived supernumerary marker the newborn was phenotypically normal. Two women with fetal mar(18) and mar(Xp) decided to terminate the pregnancy. The fifth pregnancy had a karyotype of 46,XX,-15,+der(15)t(Y:15)(q11,23;p13). A phenotypically normal girl was born at term.
KW - In situ hybridization
KW - Marker chromosome
KW - Prenatal diagnosis
UR - http://www.scopus.com/inward/record.url?scp=0028928274&partnerID=8YFLogxK
U2 - 10.1016/0028-2243(94)01964-9
DO - 10.1016/0028-2243(94)01964-9
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AN - SCOPUS:0028928274
SN - 0028-2243
VL - 59
SP - 103
EP - 107
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
IS - 1
ER -