TY - JOUR
T1 - Fluorescence in situ hybridization for the detection of trisomies 8 and 9 in polycythemia vera
AU - Amiel, A.
AU - Gaber, F.
AU - Manor, Y.
AU - Fejgin, M.
AU - Joseph-Lerner, N.
AU - Ravid, M.
AU - Lishner, M.
PY - 1995/2
Y1 - 1995/2
N2 - Trisomies 8 and 9 are the most common numerical chromosome abnormalities in polycythemia vera (PCV). Their role in the pathogenesis of the disease is unclear, however, as is their diagnostic or prognostic value. We evaluated fluorescent in situ hybridization as compared to chromosome analysis for the detection of trisomies 8 or 9 in peripheral blood cells of PCV patients. We demonstrated that FISH is a more sensitive method for the detection of the abnormalities. A positive correlation between the duration of the disease and trisomy 9 was found. FISH is a sensitive, convenient, and rapid method for the diagnosis and follow-up of chromosome aberrations in patients with PCV The application of FISH to a larger cohort of patients may provide valuable information regarding the role of the chromosomal aberrations in the initiation and progression of this disease.
AB - Trisomies 8 and 9 are the most common numerical chromosome abnormalities in polycythemia vera (PCV). Their role in the pathogenesis of the disease is unclear, however, as is their diagnostic or prognostic value. We evaluated fluorescent in situ hybridization as compared to chromosome analysis for the detection of trisomies 8 or 9 in peripheral blood cells of PCV patients. We demonstrated that FISH is a more sensitive method for the detection of the abnormalities. A positive correlation between the duration of the disease and trisomy 9 was found. FISH is a sensitive, convenient, and rapid method for the diagnosis and follow-up of chromosome aberrations in patients with PCV The application of FISH to a larger cohort of patients may provide valuable information regarding the role of the chromosomal aberrations in the initiation and progression of this disease.
UR - http://www.scopus.com/inward/record.url?scp=0028905103&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(94)00139-3
DO - 10.1016/0165-4608(94)00139-3
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AN - SCOPUS:0028905103
SN - 0165-4608
VL - 79
SP - 153
EP - 156
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
