Fluorescence imaging of lesions, deep beneath tissue surface

A diffused optical detection system for fluorescence imaging of lesions, deep beneath the tissue surface, was discussed. The conjugate interacts with the antigens expressed by the diseased tissue, resulting in fluorescent labeling of the antigen. The position of the fluorophore in the tissue was also determined by using the fluorescence imaging combined with a reconstruction algorithm developed on the bases of the random walk model. An application of a tool, based on the random-walk theory in turbid media, for extracting the pharmacokinetics of the fluorescent antibodies by data deconvolution, was also presented.