Flunitrazepam and codein for oral premedication in children

I. Dodakova, S. Evron, F. Magora

Research output: Contribution to journalArticlepeer-review


100 children (Group A) were premedicated orally with flunitrazepam syrup, 0.1-0.15 mg/kg. A group of 30 children (Group B) received in addition oral codeine phosphate, 1 mg/kg, The drugs were readily accepted by children of all age groups. In most of the children sedation began almost immediately and was followed by sleep within 10-40 minutes, which continued for about 2-3 hours. Restlessness was observed in only seven children in Group A and none in Group B. Flunitrazepam was found to be a reliable, potent hypnotic and amnestic drug with rapid absorption and thus ideal as oral premedication for children. By the addition of codeine better sedation was achieved, induction of anesthesia was smoother and concentration of halothane needed for maintenance of anesthesia was reduced by half.

Original languageEnglish
Pages (from-to)493-494+540
Issue number11-12
StatePublished - 1980
Externally publishedYes


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