@article{20e1dec5ca5e4ac497cfce4ac4b26a07,
title = "Flunarizine analgesia is mediated by μ-opioid receptors",
abstract = "We evaluated the opioid antinociceptive mechanism of the calcium channel blocker flunarizine. Flunarizine produced a dose-dependent analgesia in the hot plate test which was antagonized by general (naloxone) and μ [beta-fualtrexamine (β-FNA)]-opioid antagonists, indicating a role for μ receptors in flunarizine analgesia. Naltrindole (δ1 antagonist) did not affect flunarizine analgesia. A fixed subthreshold dose of flunarizine augmented μ (morphine) analgesia and blocked δ1, [enkephalin, [D-Pen2,5] (DPDPE)] analgesia. Apparently, flunarizine has μ agonistic activity and δ1, antagonist or mixed agonistic-antagonistic activity.",
keywords = "Analgesia, Flunarizine, Opioid receptor subtypes",
author = "Ronit Weizman and Pankova, {Irena A.} and Shaul Schreiber and Pick, {Chaim G.}",
note = "Funding Information: This work was supported in part by the Tel Aviv University Foundation for Basic Research and by a research grant from The Adams Super-Center for Brain Studies at Tel Aviv University. ",
year = "1997",
month = nov,
doi = "10.1016/S0031-9384(97)00344-2",
language = "אנגלית",
volume = "62",
pages = "1193--1195",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",
}