Fluctuations of lipid and lipoprotein levels in hyperlipidemic postmenopausal women receiving hormone replacement therapy

Moshe S. Weintraub*, Itamar Grosskopf, Gideon Charach, Nachman Eckstein, Yehuda Ringel, Nitsan Maharshak, Heschi H. Rotmensch, Ardon Rubinstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Fluctuations in lipid and lipoprotein levels are encountered quite often in hyperlipidemic patients. We examined the possibility that lipid and lipoprotein levels fluctuate due to the different effects of estrogen and progestogen in postmenopausal hyperlipidemic women receiving combined hormonal replacement therapy. Methods: In an open-label study conducted during 3 consecutive hormonal cycles (3 months), levels of fasting total cholesterol, triglycerides, and low (LDLC)- and high-density lipoprotein cholesterol (HDLC) were determined in 36 postmenopausal hyperlipidemic women on day 13 of conjugated equine estrogen (1.25 mg/d) therapy and on day 25 after 12 days of receiving estrogen plus medroxyprogesterone acetate (5 mg/d). Results: While receiving estrogen and combined therapies, means ± SD total cholesterol levels increased from 6.50 ± 0.97 mmol/L (251 ± 37 mg/dL) to 6.88 ± 1.42 mmol/L (266 ± 54 mg/dL) (P<.001); LDLC levels, from 4.05 ± 1.14 mmol/L (156 ± 44 mg/dL) to 4.62 ± 1.36 mmol/L (178 ± 52 mg/dL) (P<.001). Mean ± SD HDLC cholesterol levels decreased from 1.44 ± 0.32 mmol/L (55 ± 12 mg/dL) to 1.29 ± 0.28 mmol/L (50 ± 10 mg/dL) (P<.001); triglyceride levels, from 2.23 ± 1.03 mmol/L (197 ± 91 mg/dL) to 2.06 ± 1.04 mmol/L (182 ± 92 mg/dL) (P<.001). Conclusions: Hyperlipidemic postmenopausal women receiving combined sequential estrogen and progestogen replacement therapy demonstrate very significant fluctuations in their lipid and lipoprotein levels. These fluctuations depend on the hormonal phase, ie, estrogen alone or combined with progestogen.

Original languageEnglish
Pages (from-to)1803-1806
Number of pages4
JournalArchives of Internal Medicine
Issue number16
StatePublished - 14 Sep 1998


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