Flow cytometry and morphology analysis of bone marrow in a child with brucellosis and hematologic manifestations

Arnon Broides, George Shubinsky, Tikva Yermiahu, Abed Abu-Quider, Joseph Press, Asher Moser

Research output: Contribution to journalArticlepeer-review

Abstract

Constitutional symptoms and pancytopenia are occasionally the initial presentation of pediatric brucellosis. Therefore, in endemic areas, in children with pancytopenia, both brucellosis and malignancy should be included in the deferential diagnosis. We report here a child with pancytopenia and hepatosplenomegaly as manifestations of brucellosis in whom bone marrow morphology and flow cytometry data revealed hemophagocytosis, left shift in myeloid cells and activation changes in antigenic properties of T and B lymphocytes and monocytes. The patient had an uneventful and complete recovery after appropriate antibiotic therapy. Our report demonstrates that bone marrow and flow cytometry findings in children with brucellosis may include significant reactive changes in hematopoiesis.

Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume30
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Bone marrow
  • Brucellosis
  • Lymphocytes
  • Monocytes
  • Pancytopenia

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