TY - JOUR
T1 - Five-millimeter-incision deep lamellar endothelial keratoplasty
T2 - One-year results
AU - Yepes, Natasha
AU - Segev, Fanny
AU - Hyams, Michael
AU - McAllum, Penny
AU - Slomovic, Allan R.
AU - Rootman, David S.
PY - 2007/6
Y1 - 2007/6
N2 - PURPOSE: To evaluate visual acuity, topography, and endothelial cell density 1 year after deep lamellar endothelial keratoplasty (DLEK) for endothelial dysfunction. METHODS: This is a prospective, comparative, interventional case series. Thirty-five eyes of 35 patients who had undergone DLEK with a 5-mm incision and had a minimum of 1-year follow-up were included. Main outcome measures were best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), astigmatism, topographic regularity and symmetry, and endothelial cell density. RESULTS: One year postoperatively, BSCVA was 0.33 ± 0.12 (mean, 20/60; range, 20/40-20/400) compared with 0.15 ± 0.15 preoperatively (mean, 20/200; range, 20/70-20/800). Six patients did not reach an acceptable visual acuity and were not included in the mean BSCVA, 2 had a primary failure, and the others had preexisting glaucoma or macular disease. Spherical equivalent was -0.04 ± 1.2 D, refractive astigmatism was 1.76 ± 1.69 D, surface regularity index was 0.97 ± 0.54, and surface asymmetry index was 1.25 ± 0.78 1 year after surgery. Mean endothelial cell count from the donor was 2904 ± 559 (range, 4694-2111) and 1 year after surgery was 1595 ± 662 (range, 702-3040), equating to 45% cell loss (range, 15%-77%). CONCLUSIONS: DLEK is a newer method to replace the endothelium in patients with Fuchs dystrophy. Results showed minimal astigmatism, good topographic parameters, and acceptable visual acuity. Endothelial cell loss at 1 year was significant.
AB - PURPOSE: To evaluate visual acuity, topography, and endothelial cell density 1 year after deep lamellar endothelial keratoplasty (DLEK) for endothelial dysfunction. METHODS: This is a prospective, comparative, interventional case series. Thirty-five eyes of 35 patients who had undergone DLEK with a 5-mm incision and had a minimum of 1-year follow-up were included. Main outcome measures were best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), astigmatism, topographic regularity and symmetry, and endothelial cell density. RESULTS: One year postoperatively, BSCVA was 0.33 ± 0.12 (mean, 20/60; range, 20/40-20/400) compared with 0.15 ± 0.15 preoperatively (mean, 20/200; range, 20/70-20/800). Six patients did not reach an acceptable visual acuity and were not included in the mean BSCVA, 2 had a primary failure, and the others had preexisting glaucoma or macular disease. Spherical equivalent was -0.04 ± 1.2 D, refractive astigmatism was 1.76 ± 1.69 D, surface regularity index was 0.97 ± 0.54, and surface asymmetry index was 1.25 ± 0.78 1 year after surgery. Mean endothelial cell count from the donor was 2904 ± 559 (range, 4694-2111) and 1 year after surgery was 1595 ± 662 (range, 702-3040), equating to 45% cell loss (range, 15%-77%). CONCLUSIONS: DLEK is a newer method to replace the endothelium in patients with Fuchs dystrophy. Results showed minimal astigmatism, good topographic parameters, and acceptable visual acuity. Endothelial cell loss at 1 year was significant.
KW - Cornea transplantation
KW - Deep lamellar endothelial keratoplasty
KW - Fuchs dystrophy
KW - Posterior lamellar keratoplasty
UR - http://www.scopus.com/inward/record.url?scp=34547418696&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e318038d2ff
DO - 10.1097/ICO.0b013e318038d2ff
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C2 - 17525645
AN - SCOPUS:34547418696
SN - 0277-3740
VL - 26
SP - 530
EP - 533
JO - Cornea
JF - Cornea
IS - 5
ER -