First live birth following IVF-embryo transfer and use of GnRHa alone for ovarian stimulation

Foad Azem*, Beni Almog, Dalit Ben-Yosef, Rita Kapustiansky, Israel Wagman, Ami Amit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Several case reports have shown that some patients may develop ovarian cysts or ovarian hyperstimulation syndrome following the administration of gonadotrophin-releasing hormone agonist (GnRHa). This is the first report of a live birth following ovarian stimulation and IVF-embryo transfer using sole administration of GnRHa as part of the short protocol. The 31-year-old woman was referred to IVF because of severe male factor. Following spontaneous menses, ovulation induction was started by administering a conventional flare-up regimen (triptorelin 0.1 mg) on day 1 of the cycle. On day 3, the oestradiol concentration was 444 pg/ml and the progesterone concentration was 0.3 ng/ml. On day 4, about 10 follicles, 8-10 mm in size, were detected in each ovary, and the oestradiol concentration rose to 704 pg/ml (progesterone was unchanged). Surprisingly, on day 9, the follicles were 18-19 mm in diameter, oestradiol had increased to 3678 pg/ml and progesterone was now 2.88 ng/ml. Informed consent was obtained for administering human chorionic gonadotrophin and for performing ovum retrieval 36 h later. Nineteen MII oocytes were retrieved, and all were fertilized, yielding high-quality embryos. Two embryos were transferred, and the patient conceived and recently gave birth to a healthy singleton.

Original languageEnglish
Pages (from-to)162-164
Number of pages3
JournalReproductive BioMedicine Online
Issue number2
StatePublished - Aug 2009


  • Embryo transfer
  • GnRHa
  • IVF
  • Live birth
  • Ovarian stimulation


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