First Clinical Study of the Selective 5‐HT3 Antagonist, Granisetron (BRL 43694), in the Acute Treatment of Migraine Headache

E. G.M. Couturier; R. Hering; C. A. Foster; T. J. Steiner; F. Clifford Rose

doi:10.1111/j.1526-4610.1991.hed3105296.x

First Clinical Study of the Selective 5‐HT₃ Antagonist, Granisetron (BRL 43694), in the Acute Treatment of Migraine Headache

E. G.M. Couturier^*, R. Hering, C. A. Foster, T. J. Steiner, F. Clifford Rose

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

SYNOPSISGranisetron (BRL 43694), a selective 5‐HT₃ receptor antagonist, was assessed as acute therapy for the first time in migraine patients. In an open pilot study 7 migraine attacks were treated in 6 patients. All but I patient experienced marked and rapid relief from the headache, and nausea and vomiting were rapidly resolved in the 6 cases where these symptoms accompanied the attack. No side effects were recorded. Development of granisetron for migraine was suspended during the study for extraneous reasons.

Original language	English
Pages (from-to)	296-297
Number of pages	2
Journal	Headache
Volume	31
Issue number	5
DOIs	https://doi.org/10.1111/j.1526-4610.1991.hed3105296.x
State	Published - May 1991
Externally published	Yes

Keywords

5‐HT
acute migraine
granisetron
serotonin

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10.1111/j.1526-4610.1991.hed3105296.x

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title = "First Clinical Study of the Selective 5‐HT3 Antagonist, Granisetron (BRL 43694), in the Acute Treatment of Migraine Headache",

abstract = "SYNOPSISGranisetron (BRL 43694), a selective 5‐HT3 receptor antagonist, was assessed as acute therapy for the first time in migraine patients. In an open pilot study 7 migraine attacks were treated in 6 patients. All but I patient experienced marked and rapid relief from the headache, and nausea and vomiting were rapidly resolved in the 6 cases where these symptoms accompanied the attack. No side effects were recorded. Development of granisetron for migraine was suspended during the study for extraneous reasons.",

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AU - Foster, C. A.

AU - Steiner, T. J.

AU - Rose, F. Clifford

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AB - SYNOPSISGranisetron (BRL 43694), a selective 5‐HT3 receptor antagonist, was assessed as acute therapy for the first time in migraine patients. In an open pilot study 7 migraine attacks were treated in 6 patients. All but I patient experienced marked and rapid relief from the headache, and nausea and vomiting were rapidly resolved in the 6 cases where these symptoms accompanied the attack. No side effects were recorded. Development of granisetron for migraine was suspended during the study for extraneous reasons.

KW - 5‐HT

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KW - granisetron

KW - serotonin

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First Clinical Study of the Selective 5‐HT₃ Antagonist, Granisetron (BRL 43694), in the Acute Treatment of Migraine Headache

Abstract

Keywords

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