@article{094ec65d5a1d474788d05d9b58155b97,
title = "Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays",
abstract = "Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4+ T cells, defined by CD69 upregulation, IL-2 production and cell proliferation, correlates with aCD3 density on nanoarrays. Immobilization of aCD3 through nanopatterning had two effects: cell activation was significantly higher on these surfaces than on aCD3-coated plastics and allowed unprecedented fine-tuning of T cell response.",
keywords = "Artificial antigen presenting interfaces, CD4+ T cells, T cell activation, anti-CD3 monoclonal antibody, block copolymer micellar nanolithography (BCML), nanopattern",
author = "Jovana Matic and Janosch Deeg and Alexander Scheffold and Itamar Goldstein and Spatz, \{Joachim P.\}",
year = "2013",
month = nov,
day = "13",
doi = "10.1021/nl4022623",
language = "אנגלית",
volume = "13",
pages = "5090--5097",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "11",
}