Fine needle aspiration biopsy in patients with diffusely enlarged spleens

Michael Lishner*, Ruth Lang, Yali Hamlet, Elizabeth Halph, Zeev Steiner, J. Radnay, Mordchai Ravid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To evaluate the diagnostic value and potential risk of fine needle aspiration biopsy (FNAB) of the spleen in patients with diffuse splenomegaly due to an undetermined cause. STUDY DESIGN: Retrospective evaluation of the medical records and cytologic material from 58 patients on whom FNAB was performed between 1967 and 1993. RESULTS: Sixty-five FNABs were performed on 58 patients. Lymphoproliferative diseases were found in six; in four additional cases, metastatic adenocarcinoma, sarcoidosis, Candida albicans and enterococcal infection were demonstrated. The remaining 55 biopsies either showed normal splenic tissue or were nondiagnostic. No complications were recorded. CONCLUSION: Splenic FNAB may be useful in some patients with diffuse splenomegaly. The diagnostic yield is rather low. The procedure, however, is simple, safe and well tolerated.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalActa Cytologica
Issue number2
StatePublished - 1996


  • Aspiration biopsy
  • Splenic diseases


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