Finally, Archaea Get Their CRISPR-Cas Toolbox

Uri Gophna, Thorsten Allers, Anita Marchfelder*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations


The majority of archaea encode CRISPR-Cas systems but only a few CRISPR-Cas-based genetic tools have been developed for organisms from this domain. Nayak and Metcalf have harnessed a bacterial Cas9 protein for genome editing in Methanosarcina acetivorans, enabling efficient gene deletion and replacement.

Original languageEnglish
Pages (from-to)430-432
Number of pages3
JournalTrends in Microbiology
Issue number6
StatePublished - Jun 2017


  • CRISPR-Cas
  • Cas9
  • HDR
  • MMEJ
  • NHEJ
  • archaea


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