Fibrous dysplasia and cherubism as an hereditary familial disease. Follow-up of four generations

Yuval Zohar; Ron Grausbord; Fiorella Shabtai; Yoav Talmi

doi:10.1016/S1010-5182(89)80102-7

Fibrous dysplasia and cherubism as an hereditary familial disease. Follow-up of four generations

Yuval Zohar^*, Ron Grausbord, Fiorella Shabtai, Yoav Talmi

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Five cases of dysplasia of the jaws in one family which has been under our observation since 1970 are reported. The disease appeared as a mixed display of jaw lesions, in some members as fibrous dysplasia and in others as cherubism. We were able to trace the disorder through an unbroken line of four generations, and thus to demonstrate autosomal dominant inheritance. Cytogenetic analysis performed on three members of this family revealed a significantly increased rate of chromosomal breakage.

Original language	English
Pages (from-to)	340-342,v-vi,343-344
Journal	Journal of Cranio-Maxillofacial Surgery
Volume	17
Issue number	8
DOIs	https://doi.org/10.1016/S1010-5182(89)80102-7
State	Published - Nov 1989
Externally published	Yes

Keywords

Cherubism
Chromosome breakage
Fibrous dysplasia
Jaw lesions

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10.1016/S1010-5182(89)80102-7

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abstract = "Five cases of dysplasia of the jaws in one family which has been under our observation since 1970 are reported. The disease appeared as a mixed display of jaw lesions, in some members as fibrous dysplasia and in others as cherubism. We were able to trace the disorder through an unbroken line of four generations, and thus to demonstrate autosomal dominant inheritance. Cytogenetic analysis performed on three members of this family revealed a significantly increased rate of chromosomal breakage.",

keywords = "Cherubism, Chromosome breakage, Fibrous dysplasia, Jaw lesions",

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N2 - Five cases of dysplasia of the jaws in one family which has been under our observation since 1970 are reported. The disease appeared as a mixed display of jaw lesions, in some members as fibrous dysplasia and in others as cherubism. We were able to trace the disorder through an unbroken line of four generations, and thus to demonstrate autosomal dominant inheritance. Cytogenetic analysis performed on three members of this family revealed a significantly increased rate of chromosomal breakage.

AB - Five cases of dysplasia of the jaws in one family which has been under our observation since 1970 are reported. The disease appeared as a mixed display of jaw lesions, in some members as fibrous dysplasia and in others as cherubism. We were able to trace the disorder through an unbroken line of four generations, and thus to demonstrate autosomal dominant inheritance. Cytogenetic analysis performed on three members of this family revealed a significantly increased rate of chromosomal breakage.

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Fibrous dysplasia and cherubism as an hereditary familial disease. Follow-up of four generations

Abstract

Keywords

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