Fibrous dysplasia and cherubism as an hereditary familial disease. Follow-up of four generations

Yuval Zohar*, Ron Grausbord, Fiorella Shabtai, Yoav Talmi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Five cases of dysplasia of the jaws in one family which has been under our observation since 1970 are reported. The disease appeared as a mixed display of jaw lesions, in some members as fibrous dysplasia and in others as cherubism. We were able to trace the disorder through an unbroken line of four generations, and thus to demonstrate autosomal dominant inheritance. Cytogenetic analysis performed on three members of this family revealed a significantly increased rate of chromosomal breakage.

Original languageEnglish
Pages (from-to)340-342,v-vi,343-344
JournalJournal of Cranio-Maxillo-Facial Surgery
Volume17
Issue number8
DOIs
StatePublished - Nov 1989
Externally publishedYes

Keywords

  • Cherubism
  • Chromosome breakage
  • Fibrous dysplasia
  • Jaw lesions

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