Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand?

Jacob N. Ablin*, Dan Buskila

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Fibromyalgia syndrome (FMS) represents a unique entity within the field of rheumatology, differing from the more "classical" rheumatological disorders both in pathogenesis and in its modes of management. Gulf War syndrome (GWS) is an unusual case of a functional disorder strictly situated in a specific historical and geographical circumstance. Characterized by chronic fatigue, musculoskeletal symptoms, malaise, and cognitive impairment, GWS clinically overlaps with both post-traumatic stress disorders (PTSD) and FMS/chronic fatigue syndrome (CFS), as well as with other functional disorders. FMS and CFS are conditions with considerable clinical overlap. Fatigue is an inherent symptom of FMS, along with disturbed nonrefreshing sleep, while muscular pain is a common symptom among those diagnosed as suffering from CFS. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently described entity that encompasses symptoms from a number of clinical syndromes, including siliconosis, GWS, macrophagic myofasciitis (MMF), and post-vaccination phenomena linked with exposure to an adjuvant.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
Number of pages6
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
StatePublished - 1 Jan 2014


  • Autoimmune/inflammatory syndrome induced by adjuvants (ASIA)
  • Chronic fatigue syndrome (CFS)
  • Fibromyalgia syndrome (FMS)
  • Gulf War syndrome (GWS)
  • Post-traumatic stress disorder (PTSD)


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