Fibroblasts form a hospitable metastatic niche in the liver

Neta Erez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.

Original languageEnglish
Pages (from-to)465-466
Number of pages2
JournalNature Cell Biology
Issue number5
StatePublished - 1 May 2016


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