Fibroblasts form a hospitable metastatic niche in the liver

Neta Erez

doi:10.1038/ncb3352

Fibroblasts form a hospitable metastatic niche in the liver

Neta Erez

Pathology

Research output: Contribution to journal › Review article › peer-review

Abstract

The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.

Original language	English
Pages (from-to)	465-466
Number of pages	2
Journal	Nature Cell Biology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1038/ncb3352
State	Published - 1 May 2016

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10.1038/ncb3352

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title = "Fibroblasts form a hospitable metastatic niche in the liver",

abstract = "The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.",

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Fibroblasts form a hospitable metastatic niche in the liver

Abstract

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