TY - JOUR
T1 - Fibrin sealant
AU - Martinowitz, Uri
AU - Saltz, Renato
PY - 1996
Y1 - 1996
N2 - Fibrin sealant consists of fibrinogen and thrombin solutions, which generate a crosslinked fibrin clot in a process that mimics the last stage of the physiologic coagulation system. Fibrin sealants have been used widely in Europe in the past two decades for hemostasis, sealing, and as a vehicle for drugs and growth factors, and as a biologic glue. This review discusses the various types of fibrin sealants (autologous, homologous, commercial), their composition, mechanism of action, functional characteristics, experimental and clinical uses, limitations, complications, adverse reactions, and viral safety.
AB - Fibrin sealant consists of fibrinogen and thrombin solutions, which generate a crosslinked fibrin clot in a process that mimics the last stage of the physiologic coagulation system. Fibrin sealants have been used widely in Europe in the past two decades for hemostasis, sealing, and as a vehicle for drugs and growth factors, and as a biologic glue. This review discusses the various types of fibrin sealants (autologous, homologous, commercial), their composition, mechanism of action, functional characteristics, experimental and clinical uses, limitations, complications, adverse reactions, and viral safety.
UR - http://www.scopus.com/inward/record.url?scp=0029826687&partnerID=8YFLogxK
U2 - 10.1097/00062752-199603050-00011
DO - 10.1097/00062752-199603050-00011
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C2 - 9372108
AN - SCOPUS:0029826687
SN - 1065-6251
VL - 3
SP - 395
EP - 402
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
IS - 5
ER -