TY - JOUR
T1 - Fibrin glue for opposing wound edges in "Top Hat" penetrating keratoplasty
T2 - A laboratory study
AU - Bahar, Irit
AU - Kaiserman, Igor
AU - Slomovic, Allan
AU - McAllum, Penny
AU - Rootman, David
PY - 2007/12
Y1 - 2007/12
N2 - PURPOSE: To evaluate the advantages of fibrin glue for opposing wound edges in Top Hat penetrating keratoplasty (PKP). METHODS: Twenty human corneoscleral rims were mounted on an artificial anterior chamber. Eight corneas underwent traditional PKP, 6 underwent Top Hat PKP, and 6 underwent Top Hat PKP by using fibrin glue for opposing wound edges. Mechanical stability was evaluated after placement of 8 and 16 interrupted sutures. Wound bursting pressure and induced astigmatism were evaluated. RESULTS: In the traditional PKP group, wound bursting pressure was 25.2 and 59.1 mm Hg after placement of 8 and 16 sutures, respectively. In the Top Hat PKP, leakage occurred at 57.6 and 103.8 mm Hg after placement of the 8 and 16 sutures, respectively. In the Top Hat PKP + fibrin glue group, wound leakage occurred at 144.6 mm Hg after placement of the 8 sutures and at >158 mm Hg after placement of 16 sutures. The Top Hat PKP + fibrin glue group induced astigmatism of 2.5 D, whereas the traditional PKP group and the Top Hat PKP group showed an induced astigmatism of 3.1 D each. CONCLUSIONS: The use of fibrin glue in Top Hat PKP was found to be more mechanically stable than traditional sutures.
AB - PURPOSE: To evaluate the advantages of fibrin glue for opposing wound edges in Top Hat penetrating keratoplasty (PKP). METHODS: Twenty human corneoscleral rims were mounted on an artificial anterior chamber. Eight corneas underwent traditional PKP, 6 underwent Top Hat PKP, and 6 underwent Top Hat PKP by using fibrin glue for opposing wound edges. Mechanical stability was evaluated after placement of 8 and 16 interrupted sutures. Wound bursting pressure and induced astigmatism were evaluated. RESULTS: In the traditional PKP group, wound bursting pressure was 25.2 and 59.1 mm Hg after placement of 8 and 16 sutures, respectively. In the Top Hat PKP, leakage occurred at 57.6 and 103.8 mm Hg after placement of the 8 and 16 sutures, respectively. In the Top Hat PKP + fibrin glue group, wound leakage occurred at 144.6 mm Hg after placement of the 8 sutures and at >158 mm Hg after placement of 16 sutures. The Top Hat PKP + fibrin glue group induced astigmatism of 2.5 D, whereas the traditional PKP group and the Top Hat PKP group showed an induced astigmatism of 3.1 D each. CONCLUSIONS: The use of fibrin glue in Top Hat PKP was found to be more mechanically stable than traditional sutures.
KW - "top hat"
KW - Fibrin glue
KW - Penetrating keratoplasty
UR - http://www.scopus.com/inward/record.url?scp=36549055704&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e318151f8e8
DO - 10.1097/ICO.0b013e318151f8e8
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C2 - 18043182
AN - SCOPUS:36549055704
SN - 0277-3740
VL - 26
SP - 1235
EP - 1238
JO - Cornea
JF - Cornea
IS - 10
ER -