Fiber based comparison of whole brain tractographies with application to amyotrophic lateral sclerosis

Gali Zimmerman-Moreno*, Dafna Ben Basha, Moran Artzi, Beatrice Nefussy, Vivian Drory, Orna Aizenstein, Hayit Greenspan

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

A method is proposed for comparison between whole brain white matter tractographies derived from Diffusion Tensor Imaging (DTI) scans. The method performs fiber based comparisons between DTI-derived parameter values sampled along the fibers. The individual tractographies and the parameters sampling are done in each brain’s native space. No non-linear registration to a common space is required. Our method for fiber based comparison is especially useful as a first exploratory step in neurologic population studies. It provides pointers to the locations affected by the pathology of interest in the study. It is fully automatic and does not make any grouping assumptions on the fibers. The results are presented on a single fiber resolution level and any sub-group or tract of interest can be examined. The validation of the method was conducted using a set of scans from an Amyotrophic Lateral Sclerosis (ALS) study and comparing the outcome to previous findings.

Original languageEnglish
Pages (from-to)175-185
Number of pages11
JournalMathematics and Visualization
DOIs
StatePublished - 2014
Event16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013 - Nagoya, Japan
Duration: 22 Sep 201326 Sep 2013

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