TY - JOUR
T1 - Fetal urine analysis for the assessment of renal function in obstructive uropathy
AU - Lipitz, Shlomo
AU - Ryan, Greg
AU - Samuell, Colin
AU - Haeusler, Martin C.H.
AU - Robson, Stephen C.
AU - Dhillon, Harjeet K.
AU - Nicolini, Umberto
AU - Rodeck, Charles H.
PY - 1993
Y1 - 1993
N2 - Objectives: The assessment of fetal renal function plays a key role in the evaluation of posterior urethral valve obstruction cases. The aim of our study was to determine the value of several urinary compounds, including β2-microglobulin, N-acetyl-β-D-glucosaminidase, and microalbumin in the assessment of prenatal renal function in cases of posterior urethral valve and their potential role in the selection of such cases for in utero shunting. Study Design: A range of urinary compounds was measured, including β2-microglobulin, N-acetyl-β-D-glucosaminidase, and microalbumin in 25 cases of posterior urethral valve obstruction. These cases were divided into four groups based on outcome. The Mann-Whitney test and analysis of covariance were used. Results: Sodium, calcium, and β2-microglobulin were the best predictors for fetal survival. β2-Microglobulin values > 13 mg/L were almost invariably associated with fatal outcome. Conclusion: The estimation of β2-microglobulin may help in counseling parents and in selecting cases for in utero shunting.
AB - Objectives: The assessment of fetal renal function plays a key role in the evaluation of posterior urethral valve obstruction cases. The aim of our study was to determine the value of several urinary compounds, including β2-microglobulin, N-acetyl-β-D-glucosaminidase, and microalbumin in the assessment of prenatal renal function in cases of posterior urethral valve and their potential role in the selection of such cases for in utero shunting. Study Design: A range of urinary compounds was measured, including β2-microglobulin, N-acetyl-β-D-glucosaminidase, and microalbumin in 25 cases of posterior urethral valve obstruction. These cases were divided into four groups based on outcome. The Mann-Whitney test and analysis of covariance were used. Results: Sodium, calcium, and β2-microglobulin were the best predictors for fetal survival. β2-Microglobulin values > 13 mg/L were almost invariably associated with fatal outcome. Conclusion: The estimation of β2-microglobulin may help in counseling parents and in selecting cases for in utero shunting.
KW - Obstructive uropathy
KW - fetus
KW - β -microglobulin
UR - http://www.scopus.com/inward/record.url?scp=0027409727&partnerID=8YFLogxK
U2 - 10.1016/S0002-9378(12)90909-6
DO - 10.1016/S0002-9378(12)90909-6
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C2 - 8420322
AN - SCOPUS:0027409727
SN - 0002-9378
VL - 168
SP - 174
EP - 179
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -