@article{64c500b8b29046198de9eaec2685e428,
title = "Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors",
abstract = "High densities of serotonergic 5-HT1A receptors, in excess of adult levels, were found in the human fetal brain between the 16th and 22nd weeks of gestation. 5-HT1A receptors were measured by quantitative autoradiography using brain sections of fetuses aborted at gestational ages 16-22 weeks. The highest receptor concentrations were detected in the cortex and hippocampus. Two brains obtained from fetuses with Down's syndrome at 22 and 24 weeks gestation exhibited abnormal receptor levels compared to age matched controls. The presence of an early, prenatal peak of 5-HT1A receptors in fetal cortex and hippocampus suggests that these receptors play a role in human brain development and may also be involved in developmental disorders such as Down's syndrome.",
keywords = "5-HT receptor, Down's syndrome, Fetal human brain",
author = "Osnat Bar-Peled and Ruth Gross-Isseroff and Herzl Ben-Hur and Iffath Hoskins and Yoram Groner and Anat Biegon",
note = "Funding Information: We thank Dr. S. Gorbatz and M. Wolff from Kaplan Hospital and Y. Rabinovich from Sheba Medical Center for their great help in obtaining the brains. This work was supported by grants from the National Institute of Health HD21229, the Schilling-Stiftung fur Medizi-nische Forschung and by the Weizmann Institute, Forchheimer Center of Molecular Genetics.",
year = "1991",
month = jun,
day = "24",
doi = "10.1016/0304-3940(91)90787-T",
language = "אנגלית",
volume = "127",
pages = "173--176",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",
}