Fetal Brain Development: Regulating Processes and Related Malformations

Zvi Leibovitz, Tally Lerman-Sagie, Leila Haddad

Research output: Contribution to journalReview articlepeer-review

Abstract

This paper describes the contemporary state of knowledge regarding processes that regulate normal development of the embryonic–fetal central nervous system (CNS). The processes are described according to the developmental timetable: dorsal induction, ventral induction, neurogenesis, neuronal migration, post-migration neuronal development, and cortical organization. We review the current literature on CNS malformations associated with these regulating processes. We specifically address neural tube defects, holoprosencephaly, malformations of cortical development (including microcephaly, megalencephaly, lissencephaly, cobblestone malformations, gray matter heterotopia, and polymicrogyria), disorders of the corpus callosum, and posterior fossa malformations. Fetal ventriculomegaly, which frequently accompanies these disorders, is also reviewed. Each malformation is described with reference to the etiology, genetic causes, prenatal sonographic imaging, associated anomalies, differential diagnosis, complimentary diagnostic studies, clinical interventions, neurodevelopmental outcome, and life quality.

Original languageEnglish
Article number809
JournalLife
Volume12
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • brain development
  • CNS malformations
  • fetal neurology

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