Fertilization and early embryology: Female age does not affect the capacity of human zona pellucida to bind spermatozoa

H. Yavetz*, R. Gamzu, A. Botchan, A. Amit, J. B. Lessing, G. Paz, L. Yogev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The purpose of this study was to evaluate the effect of female age on the capacity of the zona pellucida to bind spermatozoa. A total of 1008 unfertilized oocytes obtained from 210 women (aged 21-43 years) participating in the in-vitro fertilization programme were tested using a hemizona assay. Spermatozoa taken from a cryopreserved pool of fertile donor specimens served as a control in the hemizona assay, and were used to assess the ability of the zona pellucida to bind spermatozoa. The mean ± SD number of spermatozoa attached to the hemizona was 107 ± 42. The binding capacity of different oocytes from the same cohort varied substantially (coefficient of variation = 28%). Age was not found to be correlated with the number of spermatozoa bound to the zona pellucida (r = -0.02; P > 0.1). It was concluded that female age has no role in the ability of the human zona pellucida to bind spermatozoa. Key words: female age/spermatozoa/zona binding.

Original languageEnglish
Pages (from-to)2368-2370
Number of pages3
JournalHuman Reproduction
Volume10
Issue number9
DOIs
StatePublished - Sep 1995

Keywords

  • Female age
  • Spermatozoa
  • Zona binding

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