Fertility outcome following combined methotrexate treatment of unruptured extrauterine pregnancy

Abraham Debby, Abraham Golan, Oscar Sadan, Haim Zakut, Marek Glezerman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective To assess the effectiveness of systemic treatment with methotrexate in combination with local injection for unruptured tubal pregnancy, and to evaluate reproductive function following treatment. Design Prospective, open clinical study. Setting University clinic. Population Sixty-seven women with unruptured tubal pregnancy. Methods Systemic methotrexate (intramuscular methotrexate 0.5 mg/kg for up to five days) in combination with local application of 12.5 mg methotrexate via laparoscopy. Main outcome measures The subsequent surgical intervention required and future fertility. Results In 89.6% of women no further surgical intervention was required and 47 women (81%) experienced subsequently an intrauterine pregnancy. In 39 of 40 women who underwent hysterosalpingo-graphy following treatment, patency of the affected tube was observed. Conclusions Combined local and systemic methotrexate treatment for unruptured tubal pregnancy seems to be more effective than each therapeutic modality alone.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number5
StatePublished - May 2000


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