Fertility and pregnancy complications following chorioamnionitis

Daniel Shai, Raoul Orvieto, Or Touval, Amit Ridnik, Roni Zemet, Jigal Haas*, Ravit Nahum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Acute chorioamnionitis complicates 1–2% of all pregnancies and might increase the prevalence of endometritis that can cause Asherman syndrome or adhesions, but little is known about the direct effects of chorioamnionitis on future fertility. We aimed to evaluate the effect of chorioamnionitis on future fertility and obstetrics complications in patients diagnosed with chorioamnionitis during their pregnancy. We performed an observational, case–control retrospective study of pregnant women aged 18–40 years old, hospitalized with a diagnosis of chorioamnionitis between January 2013 and December 2017. The control group consisted of patients with similar demographic/obstetrics characteristics, matched with a ratio of 1:2 without chorioamnionitis. The prevalence of post gestational diagnostic hysteroscopy was significantly higher in the study group as compared to the control group (22.9% versus 9.0%, respectively; p = 0.005). Moreover, the study group underwent significantly more operative hysteroscopy compared to the control group (10.8% versus 3.6%, respectively; p = 0.04). The patients in the study group had significantly higher prevalence of miscarriages (27% versus 13.2%, respectively; p < 0.01). We conclude that chorioamnionitis may cause endometritis with the consequent impaired fertility, necessitating comprehensive evaluations for secondary infertility, including hysteroscopy aiming to treat intrauterine adhesions that may affect and impair fertility.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalHuman Fertility
Issue number3
StatePublished - 2023


  • Asherman
  • Chorioamnionitis
  • hysteroscopy
  • infertility
  • pregnancy outcome
  • thin endometrium


Dive into the research topics of 'Fertility and pregnancy complications following chorioamnionitis'. Together they form a unique fingerprint.

Cite this