Fentanyl-droperidol neuroleptanalgesia in gastrointestinal endoscopy

Paul Rozen, Jacob Ratan, Tuvia Gilat

Research output: Contribution to journalArticlepeer-review


Intravenous diazepam, following a narcotic and atropine, provides adequate premedication for the majority of gastrointestinal endoscopic examinations. However, in certain patients there is inadequate cooperation and even paradoxical excitation. This seems more so in young, anxious patients and in chronic users of diazepam or tranquilizers. The usefulness of neuroleptanalgesia was examined by randomly giving such patients atropine, fentanyl, and diazepam or droperidol intravenously. The degree of cooperation, confusion, amnesia, recovery time, side effects, blood pressure, pulse, and respiratory rates were noted. Cooperation was inadequate in 33% of those receiving diazepam; it was adequate or good in all those receiving droperidol. The degree of somnolence and amnesia was more marked with diazepam as was confusion (24%) which did not occur following droperidol. There were otherwise no significant differences in the response of the 2 groups. Neuroleptanalgesia is useful in selected ambulatory patients, particularly in those who are acutely anxious or chronic users of diazepam.

Original languageEnglish
Pages (from-to)142-144
Number of pages3
JournalGastrointestinal Endoscopy
Issue number3
StatePublished - 1977


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