Femoral vascular closure device use, bivalirudin anticoagulation, and bleeding after primary angioplasty for STEMI: Results from the HORIZONS-AMI trial

Timothy A. Sanborn*, Matthew I. Tomey, Roxana Mehran, Philippe Ǵeńereux, Bernhard Witzenbichler, Sorin J. Brener, Ajay J. Kirtane, Thomas C. McAndrew, Ran Kornowski, Dariusz Dudek, Eugenia Nikolsky, Gregg W. Stone

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the relationship of femoral vascular closure device (VCD) use to bleeding and ischemic events in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) via different anticoagulation strategies. Background: It is unknown whether femoral VCD reduce major bleeding after primary PCI for STEMI using bivalirudin anticoagulation. Methods: We compared VCD-treated patients with propensity-matched controls in the HORIZONS-AMI trial with respect to net adverse clinical events (NACE), defined as the composite of major bleeding unrelated to coronary artery bypass graft surgery (CABG) and major adverse cardiac events (comprised of death, reinfarction, ischemia-driven target vessel revascularization, and stroke), at 30 days and 1 year. Results: Among 3,602 patients enrolled in HORIZONS-AMI, 2,948 underwent primary PCI via femoral arterial access and 896 (30%) received VCDs, of whom 642 were included in our model along with 642 propensity-matched controls. At 30 days, VCD-treated patients had significantly less NACE (6.7% vs. 10.8%, HR: 0.61, 95% CI: 0.42-0.89, P = 0.009), driven by a lower rate of non-CABG related major bleeding (5.0% vs. 8.1%, HR: 0.61, 95% CI: 0.39-0.94, P = 0.02). Bleeding reduction was maintained at one year and consistent in magnitude regardless of randomization to bivalirudin or unfractionated heparin plus a glycoprotein IIb/IIIa inhibitor (P for interaction = 0.84). Conclusion: In patients undergoing transfemoral primary PCI for STEMI, VCD use was associated with significantly lower non-CABG major bleeding irrespective of anticoagulation strategy.

Original languageEnglish
Pages (from-to)371-379
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume85
Issue number3
DOIs
StatePublished - 1 Feb 2015
Externally publishedYes

Keywords

  • Bivalirudin
  • Heparin
  • Primary percutaneous coronary intervention
  • ST-segment elevation myocardial infarction
  • Vascular closure device

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