TY - JOUR
T1 - Feeding tolerance in preterm infants
T2 - Randomized trial of bolus and continuous feeding
AU - Dollberg, Shaul
AU - Kuint, Jacob
AU - Mazkereth, Ram
AU - Mimouni, Francis B.
PY - 2000
Y1 - 2000
N2 - Objective: To test the hypothesis that continuous gastric infusion (CGI) is better tolerated than intermittent gastric bolus (IGB) in small very low birth weight (VLBW) infants. Design: Two-center, prospective, randomized, unmasked clinical trial. Patients: 28 VLBW infants (birth weight <1250 g). A strict feeding protocol was followed. Intervention: Patients were randomized to IGB or CGI. Main outcome measures: Time to reach full feeds (160 cc/kg/d)(by design and real), daily weight, caloric intake, residual gastric volume and type of feeding (formula vs. human milk vs. both). Results: Five infants failed to complete the study because of death (n = 4) or protocol violation (n = 1). The two groups did not differ by birth weight or gestational age; infants fed via IGB reached full feeds earlier (p = 0.03) and had less delay in reaching full feeds than infants fed via CGI. Conclusion: Contrary to our hypothesis, gravity IGB is more effective than CGI in improving feeding tolerance in small VLBW infants.
AB - Objective: To test the hypothesis that continuous gastric infusion (CGI) is better tolerated than intermittent gastric bolus (IGB) in small very low birth weight (VLBW) infants. Design: Two-center, prospective, randomized, unmasked clinical trial. Patients: 28 VLBW infants (birth weight <1250 g). A strict feeding protocol was followed. Intervention: Patients were randomized to IGB or CGI. Main outcome measures: Time to reach full feeds (160 cc/kg/d)(by design and real), daily weight, caloric intake, residual gastric volume and type of feeding (formula vs. human milk vs. both). Results: Five infants failed to complete the study because of death (n = 4) or protocol violation (n = 1). The two groups did not differ by birth weight or gestational age; infants fed via IGB reached full feeds earlier (p = 0.03) and had less delay in reaching full feeds than infants fed via CGI. Conclusion: Contrary to our hypothesis, gravity IGB is more effective than CGI in improving feeding tolerance in small VLBW infants.
KW - Infant nutrition
KW - Prematurity
KW - Weight gain
UR - http://www.scopus.com/inward/record.url?scp=0034500511&partnerID=8YFLogxK
U2 - 10.1080/07315724.2000.10718080
DO - 10.1080/07315724.2000.10718080
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AN - SCOPUS:0034500511
SN - 0731-5724
VL - 19
SP - 797
EP - 800
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
IS - 6
ER -