TY - JOUR
T1 - FeCl3-Mediated side chain modification of aspartic Acid- and glutamic acid-containing peptides on a solid support
AU - Giri, Rajat Subhra
AU - Manne, Srinivasa Rao
AU - Dolai, Gobinda
AU - Paul, Ashim
AU - Kalita, Tapasi
AU - Mandal, Bhubaneswar
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - An efficient, convenient, and selective Lewis acid-based strategy for on-resin deprotection of the side chain tert-butyl-protected aspartic acid and glutamic acid of a peptide is achieved. The method is mild, cost-effective, and Fmoc chemistry compatible and allows on-resin incorporation of amides, esters, and thioesters in good yield. This method will find wide applicability in peptide and protein modification because it enriches the toolbox of orthogonal protection/deprotection techniques.
AB - An efficient, convenient, and selective Lewis acid-based strategy for on-resin deprotection of the side chain tert-butyl-protected aspartic acid and glutamic acid of a peptide is achieved. The method is mild, cost-effective, and Fmoc chemistry compatible and allows on-resin incorporation of amides, esters, and thioesters in good yield. This method will find wide applicability in peptide and protein modification because it enriches the toolbox of orthogonal protection/deprotection techniques.
UR - http://www.scopus.com/inward/record.url?scp=85032641490&partnerID=8YFLogxK
U2 - 10.1021/acsomega.7b01143
DO - 10.1021/acsomega.7b01143
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AN - SCOPUS:85032641490
SN - 2470-1343
VL - 2
SP - 6586
EP - 6597
JO - ACS Omega
JF - ACS Omega
IS - 10
ER -