Fecal transplant for recurrent clostridium difficile infection in children with and without inflammatory bowel disease

George H. Russell*, Jess L. Kaplan, Ilan Youngster, Mariah Baril-Dore, Lili Schindelar, Elizabeth Hohmann, Harland S. Winter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ten children at our institution received single-infusion fecal microbiome transplant (FMT) using healthy, related screened donor stool to treat recurrent Clostridium difficile infection (RCDI) via nasogastric tube (2 patients) or colonoscopic delivery. Nine of the 10 (90%) children had resolution of their symptoms after a single-infusion FMT with follow-up of 1 month to 4 years. No concerning related adverse events were recognized during short-or long-term follow-up. Three of these children had concomitant inflammatory bowel disease and 2 of these 3 (66%) patients cleared RCDI with no clinical change in their underlying inflammatory bowel disease clinical activity as assessed by Physician's Global Assessment. All of the patients who had clinical improvement of gastrointestinal symptoms of RCDI while treated with antibiotics had lasting return of baseline health after FMT.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume58
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Crohn disease
  • fecal microbiome transplant
  • inflammatory bowel disease
  • recurrent Clostridium difficile infection
  • ulcerative colitis

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