Feasibility of fertility preservation in young females with Turner syndrome

Nga Man Lau, Jack Yu Jen Huang, Suzanne MacDonald, Shai Elizur, Yariv Gidoni, Hananel Holzer, Ri Cheng Chian, Togas Tulandi, Seang Lin Tan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Women with Turner syndrome (TS) are at risk of premature ovarian failure. The objective of this retrospective study was to identify patients with TS who could be potential candidates for fertility preservation and to determine their present reproductive and fertility status. Criteria for fertility preservation included: (i) spontaneous menarche; (ii) confirmation by ultrasound examination of the presence of at least one normal ovary; and (iii) serum FSH concentrations below 40 IU/1. Using the Montreal Children's Hospital Cytogenetic Database from 1990 to 2006, 28 patients with complete or partial absence of one X chromosome were identified: 13 (46%) were 45,X; nine (32%) had mosaic karyotypes; and six (21%) had karyotypes containing isochromosome or ring X chromosome. Six patients (21%) had spontaneous pubertal development and four (14%) were identified as potential candidates for fertility preservation. One underwent an ovarian stimulation protocol of gonadotrophin-releasing hormone agonist down-regulation followed by recombinant FSH and human menopausal gonadotrophin stimulation. Two metaphase-II-stage oocytes were aspirated and vitrified using the McGill Cryoleaf vitrification system. Another patient conceived spontaneously at the age of 24 years. In conclusion, fertility preservation may not be feasible for most patients with TS. However, after careful consideration of increased pregnancy-associated risks, fertility preservation may be offered to young females with mosaic TS.

Original languageEnglish
Pages (from-to)290-295
Number of pages6
JournalReproductive BioMedicine Online
Issue number2
StatePublished - Feb 2009
Externally publishedYes


  • 45X
  • FSH
  • Fertility preservation
  • Oocyte cryopreservation
  • Premature ovarian failure
  • Turner syndrome


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