Feasibility and safety of percutaneous laser revascularization using the Biosense® system in porcine hearts

Ran Kornowski, Mun K. Hong, Christian C. Haudenschild, Martin B. Leon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background. Direct myocardial revascularization (DMR) is being explored to improve symptoms in patients with refractory ischemic coronary syndromes. This study assessed the safety and feasibility of percutaneous DMR using the Biosense® non-fluoroscopic navigation system (incorporating the holmium : yttrium aluminium garnet laser) in pig hearts. Methods and results. Twenty pigs underwent left ventricular mapping using the Biosense® system, followed by percutaneous DMR with a holmium : yttrium aluminium garnet laser at 2 J x 1 pulse, and were sacrificed acutely (n = 5), at 24 h (n = 5), and at 3 weeks (n = 10) after the DMR procedure. The hearts were examined grossly and microscopically. Serial creatine kinase-MB level was measured up to 24 h. There were no procedural complications. Animals received 13 ± 2 channels in 19 ± 7 min. The catheter was able to reach all regions, including the septum. There was no increase in creatine kinase-MB level up to 24 h. One animal died within an hour of the procedure. There was one sealed perforation into the subepicardial fat as a result of same site laser activation. Histologic evaluation in the acute and 24 h groups revealed laser channels which were 3.6 ± 2.2 mm long, 1.5 ± 0.7 mm wide, with an entry angle of 73 ± 12°. Channels were filled with platelet thrombi acutely and were surrounded by well-defined rims of thermal coagulation and an 'impact zone' of viable myocardium; at 3 weeks, no channels remained patent and they had been replaced by well-healed granulation tissue. Conclusions. It is feasible and safe to perform percutaneous DMR with the Biosense® system and the channels created with the chosen laser parameters are rapidly sealed with platelet thrombi and at 3 weeks are replaced by well-healed granulation tissue.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalCoronary Artery Disease
Issue number8
StatePublished - 1998
Externally publishedYes


  • Direct myocardial revascularization
  • Ischemic heart disease
  • Laser


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