TY - JOUR
T1 - Favorable response of pediatric AIDS‐related Burkitt's lymphoma treated by aggressive chemotherapy
AU - Neumann, Yoram
AU - Toren, Amos
AU - Mandel, Matilda
AU - Martinowitz, Uri
AU - Varon, David
AU - Ramot, Bracha
AU - Ben‐Bassat, Isaac
AU - Rechavi, Gideon
PY - 1993
Y1 - 1993
N2 - We describe 4 male children infected by the human immunodeficiency virus (HIV) who developed Burkitt's lymphoma during their disease. The clinical picture was characterized by an insidious appearance of symptoms. All the children suffered for several months from abdominal discomfort and a gradual elevation of their blood lactic dehydrogenase (LDH) level prior to diagnosis. Bone marrow involvement was found in 2 of the patients and jaw involvement in the other 2. After confirming the diagnosis of Burkitt's lymphoma, they were treated according to conventional protocols, with no need to reduce the dose intensity. They all went into complete remission and did not suffer from major opportunistic infections during chemotherapy. None of them relapsed. Two patients died from opportunistic infections 1 and 3 years after diagnosis. The other 2 are alive, 7 years and 6 months after diagnosis. The various characteristics of this unique pediatric group are described and the comparison of the clinical picture in adults is made, together with a review of the relevant literature. © 1993 Wiley‐Liss, Inc.
AB - We describe 4 male children infected by the human immunodeficiency virus (HIV) who developed Burkitt's lymphoma during their disease. The clinical picture was characterized by an insidious appearance of symptoms. All the children suffered for several months from abdominal discomfort and a gradual elevation of their blood lactic dehydrogenase (LDH) level prior to diagnosis. Bone marrow involvement was found in 2 of the patients and jaw involvement in the other 2. After confirming the diagnosis of Burkitt's lymphoma, they were treated according to conventional protocols, with no need to reduce the dose intensity. They all went into complete remission and did not suffer from major opportunistic infections during chemotherapy. None of them relapsed. Two patients died from opportunistic infections 1 and 3 years after diagnosis. The other 2 are alive, 7 years and 6 months after diagnosis. The various characteristics of this unique pediatric group are described and the comparison of the clinical picture in adults is made, together with a review of the relevant literature. © 1993 Wiley‐Liss, Inc.
KW - HIV
KW - abdominal discomfort
KW - bone marrow
KW - children
KW - lactic dehydrogenase
UR - http://www.scopus.com/inward/record.url?scp=0027521789&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950210910
DO - 10.1002/mpo.2950210910
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AN - SCOPUS:0027521789
SN - 0098-1532
VL - 21
SP - 661
EP - 664
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 9
ER -
