Fatty acid balance regulates α-synuclein pathology

Stav Cohen-Adiv, Avraham Ashkenazi

Research output: Contribution to journalShort surveypeer-review


A recent study by Triphati et al. used a protein engineering approach to demonstrate that cellular stress caused by familial α-synuclein mutations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that metabolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.

Original languageEnglish
JournalTrends in Neurosciences
StateAccepted/In press - 2022


  • Parkinson's disease
  • aggregation-prone proteins
  • cellular membrane
  • monounsaturated fatty acid
  • α-synuclein


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