Fatal pulmonary artery thrombosis in a patient with Behcet's disease, activated protein C resistance and hyperhomocystinemia

M. Misgav, Y. Goldberg, D. Zeltser, A. Eldor, A. S. Berliner

Research output: Contribution to journalArticlepeer-review

Abstract

Behcet's disease (BD) is known for its tendency for thromboembolism, which is thought to be due to vascular injury. The important role of inherited thrombophilias is now becoming increasingly clear. However, conflicting data exist in terms of the contribution of these factors to the thrombotic risk in BD. In this case report, we describe a patient with BD who presented with severe cor pulmonale due to recurrent chronic venous thromboembolism and pulmonary artery thrombosis. The biochemical evaluation revealed that the patient was homozygotic for the factor V Leiden (R506Q) mutation and had increased levels of homocysteine. His condition deteriorated despite adequate anticoagulation treatment, and he died suddenly after 7 months of follow-up. We assume that the presence of thrombophilic risk factors augments and synergizes with the hypercoagulable state already existing in BD, leading to fatal thrombosis in this patient. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)421-423
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume11
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Behcet's disease
  • Factor V Leiden
  • Homocysteine
  • Thromboembolism
  • Thrombophilia

Fingerprint

Dive into the research topics of 'Fatal pulmonary artery thrombosis in a patient with Behcet's disease, activated protein C resistance and hyperhomocystinemia'. Together they form a unique fingerprint.

Cite this