TY - JOUR
T1 - Fatal outcome following foetal cerebellar haemorrhage associated with placental thrombosis
AU - Malinger, Gustavo
AU - Zahalka, Neriman
AU - Kidron, Dvora
AU - Ben-Sira, Liat
AU - Lev, Dorit
AU - Lerman-Sagie, Tally
PY - 2006/3
Y1 - 2006/3
N2 - Cerebellar haemorrhage is a rare prenatal event. Possible aetiologies for foetal intracranial haemorrhage include: trauma, asphyxia, infection, vascular defects, blood dyscrasias, ingestion of drugs and alloimmune and isoimmune thrombocytopenia. We report the ultrasonographic diagnosis of a cerebellar haematoma at 21 weeks of gestation. The foetus succumbed at 33 weeks of gestation following rupture of a subcapsular liver haematoma. An autopsy demonstrated a placental foetal thrombotic vasculopathy and thrombi in the chorionic vessels. We assume that hypercoagulability was responsible for the multiple infarcts in the foetus with haemorrhagic transformation in the cerebellum and liver. The differential diagnosis of foetal cerebellar haemorrhage includes maternal hypercoagulability; in this case multiple haemorrhagic/ischaemic events may be encountered during the pregnancy. A thorough investigation to elucidate the aetiology is pertinent in every case of foetal cerebellar haemorrhage in order to enable accurate counselling and correct management.
AB - Cerebellar haemorrhage is a rare prenatal event. Possible aetiologies for foetal intracranial haemorrhage include: trauma, asphyxia, infection, vascular defects, blood dyscrasias, ingestion of drugs and alloimmune and isoimmune thrombocytopenia. We report the ultrasonographic diagnosis of a cerebellar haematoma at 21 weeks of gestation. The foetus succumbed at 33 weeks of gestation following rupture of a subcapsular liver haematoma. An autopsy demonstrated a placental foetal thrombotic vasculopathy and thrombi in the chorionic vessels. We assume that hypercoagulability was responsible for the multiple infarcts in the foetus with haemorrhagic transformation in the cerebellum and liver. The differential diagnosis of foetal cerebellar haemorrhage includes maternal hypercoagulability; in this case multiple haemorrhagic/ischaemic events may be encountered during the pregnancy. A thorough investigation to elucidate the aetiology is pertinent in every case of foetal cerebellar haemorrhage in order to enable accurate counselling and correct management.
KW - Cerebellar haemorrhage
KW - Foetal brain
KW - Foetal thrombotic vasculopathy
KW - Placental thrombosis
KW - Prenatal diagnosis
KW - Subcapsular liver haematoma
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=33646196918&partnerID=8YFLogxK
U2 - 10.1016/j.ejpn.2006.02.002
DO - 10.1016/j.ejpn.2006.02.002
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C2 - 16567118
AN - SCOPUS:33646196918
VL - 10
SP - 93
EP - 96
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
SN - 1090-3798
IS - 2
ER -