Fatal outcome following foetal cerebellar haemorrhage associated with placental thrombosis

Gustavo Malinger, Neriman Zahalka, Dvora Kidron, Liat Ben-Sira, Dorit Lev, Tally Lerman-Sagie

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebellar haemorrhage is a rare prenatal event. Possible aetiologies for foetal intracranial haemorrhage include: trauma, asphyxia, infection, vascular defects, blood dyscrasias, ingestion of drugs and alloimmune and isoimmune thrombocytopenia. We report the ultrasonographic diagnosis of a cerebellar haematoma at 21 weeks of gestation. The foetus succumbed at 33 weeks of gestation following rupture of a subcapsular liver haematoma. An autopsy demonstrated a placental foetal thrombotic vasculopathy and thrombi in the chorionic vessels. We assume that hypercoagulability was responsible for the multiple infarcts in the foetus with haemorrhagic transformation in the cerebellum and liver. The differential diagnosis of foetal cerebellar haemorrhage includes maternal hypercoagulability; in this case multiple haemorrhagic/ischaemic events may be encountered during the pregnancy. A thorough investigation to elucidate the aetiology is pertinent in every case of foetal cerebellar haemorrhage in order to enable accurate counselling and correct management.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalEuropean Journal of Paediatric Neurology
Volume10
Issue number2
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • Cerebellar haemorrhage
  • Foetal brain
  • Foetal thrombotic vasculopathy
  • Placental thrombosis
  • Prenatal diagnosis
  • Subcapsular liver haematoma
  • Ultrasound

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