TY - JOUR
T1 - Famotidine has no effect on cardiac performance and liver blood flow in the rat
AU - Melzer, Ehud
AU - Bardan, Eytan
AU - Krepel, Zipora
AU - Bar-Meir, Simon
PY - 1994/12
Y1 - 1994/12
N2 - Conflicting results have been reported on the effect of famotidine on cardiac performance and visceral hemodynamics, studied by non-invasive techniques. It is for that reason that we used the radioactive microsphere technique to study the effect of famotidine on cardiac performance in the rat. Hepatic blood flow (HBF) and portal blood flow (PBF) were measured during the same experiment. Rats were either given famotidine (2.0 mg/kg per day) or drinking water for 7 days through an orogastric tube. Administration of famotidine had no effect on cardiac output (CO), HBF, PBF, or liver blood flow (LBF), which is the sum of HBF and PBF. In both groups, LBF consisted of a similar fraction of CO, 14.5±3.9% and 15.7±4.38%, in the control and the famotidine groups, respectively. Pulse rate, systolic pressure and left ventricular contractility were not affected by famotidine. It is concluded that in the rat, administration of famotidine for 7 days has no effect on systemic, hepatic or portal hemodynamics.
AB - Conflicting results have been reported on the effect of famotidine on cardiac performance and visceral hemodynamics, studied by non-invasive techniques. It is for that reason that we used the radioactive microsphere technique to study the effect of famotidine on cardiac performance in the rat. Hepatic blood flow (HBF) and portal blood flow (PBF) were measured during the same experiment. Rats were either given famotidine (2.0 mg/kg per day) or drinking water for 7 days through an orogastric tube. Administration of famotidine had no effect on cardiac output (CO), HBF, PBF, or liver blood flow (LBF), which is the sum of HBF and PBF. In both groups, LBF consisted of a similar fraction of CO, 14.5±3.9% and 15.7±4.38%, in the control and the famotidine groups, respectively. Pulse rate, systolic pressure and left ventricular contractility were not affected by famotidine. It is concluded that in the rat, administration of famotidine for 7 days has no effect on systemic, hepatic or portal hemodynamics.
KW - Cardiac output
KW - Famotidine
KW - Liver blood flow
UR - http://www.scopus.com/inward/record.url?scp=0028285996&partnerID=8YFLogxK
U2 - 10.1007/BF02576378
DO - 10.1007/BF02576378
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C2 - 8091015
AN - SCOPUS:0028285996
SN - 0300-9130
VL - 194
SP - 179
EP - 184
JO - Research in Experimental Medicine
JF - Research in Experimental Medicine
IS - 1
ER -