Family-based association study of 5-HT2A receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents

Gil Zalsman*, Amos Frisch, Ruth Baruch-Movshovits, Leo Sher, Elena Michaelovsky, Robert A. King, Tsvi Fischel, Haggai Hermesh, Pablo Goldberg, Marianne Gorlyn, Sagit Misgav, Alan Apter, Sam Tyano, Abraham Weizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Suicidal behavior runs in families and is partially genetically determined. Since greater serotonin 5-HT2A receptor binding has been reported in postmortem brain and platelets of suicide victims, the 5-HT2A receptor gene polymorphism T102C became one of the candidate sites in the study of suicide and impulsive-aggressive traits. However, studies that examined the association of this polymorphism with suicidality have contradictory results. This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association. Methods: Thirty families of inpatient adolescents from Jewish Ashkenazi origin, with a recent suicide attempt, were genotyped. All subjects were interviewed for clinical diagnosis, depressive and impulsive-aggressive traits and demographic data. Allele frequencies were assessed using the Haplotype Relative Risk method for trios. Results: No difference was found in allelic distribution between transmitted and non-transmitted alleles. There was no significant association of genotype with any of the clinical traits. Conclusions: These preliminary results suggest that the 5-HT2A T102C polymorphism is unlikely to be associated with suicidal behavior and related traits in adolescent suicide attempters.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalInternational Journal of Adolescent Medicine and Health
Volume17
Issue number3
DOIs
StatePublished - 2005

Funding

FundersFunder number
Charles E. Smith Family99/9b
National Institute for Psychobiology in Israel

    Keywords

    • Family-based study
    • Genetics
    • Haplotype relative risk (HRR)
    • Israel
    • Polymorphism
    • Serotonin receptor 2A (5HT)
    • Suicide

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