Familial solitary hypogonadotropism (Hebrew)

H. Zakut, S. Mashiach, V. Insler

Research output: Contribution to journalArticlepeer-review


Primary failure of the pituitary secretion of gonadotropins alone is very rare. Most cases are usually sporadic and familial. 3 members of the same family, 2 women and 1 man, with solitary hypogonadotropism are reported. All suffered from primary sterility proved to be due to hypogonadotropism. Their adrenal and thyroid functions were normal. After combined treatment with human menopausal gonadotropins and human chorionic gonadotropins the women became pregnant and delivered. The man stopped treatment. There seems to be a common genetic facto, possibly an autosomal recessive gene, which could be detected when the children born after treatment reach sexual maturity.

Original languageEnglish
Pages (from-to)356-358+385
Issue number8
StatePublished - 1974
Externally publishedYes


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