TY - JOUR
T1 - Familial sinistrality and handedness in patients with first episode schizophrenia
T2 - The EUFEST study
AU - Dollfus, S.
AU - Alary, M.
AU - Razafimandimby, A.
AU - Prelipceanu, D.
AU - Rybakowski, J. K.
AU - Davidson, M.
AU - Galderisi, S.
AU - Libiger, J.
AU - Hranov, L. G.
AU - Hummer, M.
AU - Boter, H.
AU - Peuskens, J.
AU - Kahn, R. S.
AU - Fleischhacker, W. W.
N1 - Funding Information:
MD has received research grant support, travel support, speaker fees, or consultancy fees from JNJ, Pfizer, Lundbeck, Teva, BioLineRx, Eli Lilly, Sanofi-Aventis, Roche, Servier, and Tangent Data.
Funding Information:
WWF has received research grants from BMS/Otsuka, Eli Lilly, Janssen-Cilag, Pfizer, and Servier; honoraria for educational programmes from AstraZeneca and Pfizer; speaking fees from AstraZeneca, BMS/Otsuka, Janssen-Cilag, Lundbeck, and Pfizer; and advisory board honoraria from AstraZeneca, BMS/Otsuka, Eli Lilly, Janssen-Cilag, Merck, Pfizer, Servier, Targacept, UBC, and Wyeth.
Funding Information:
This work was funded by the European Group for Research in Schizophrenia (EGRIS) with grants from AstraZeneca, Pfizer, and Sanofi-Aventis. Neither the EGRIS nor any sponsor had any further role in study design, in the collection, analysis, or interpretation of data, in the writing of the report, or in the decision to submit the paper for publication.
Funding Information:
JP has received consultancy fees and research grants and participated in clinical trials sponsored by AstraZeneca, Sanofi-Aventis, Eli Lilly, Pfizer, and Janssen-Cilag.
PY - 2012/3
Y1 - 2012/3
N2 - The population with schizophrenia is characterised by a leftward shift in handedness-sinistrality. However, findings are inconsistent in chronic patients, and familial sinistrality (FS), defined as the presence of left-handed close relatives, might contribute to the discrepancies. Therefore the aim of this study was to investigate the strength of manual lateralisation in patients with first episode schizophrenia, taking into account familial sinistrality. The Edinburgh Inventory (EI) allowed us to categorise 179 patients from the EUFEST study and 189 controls presenting "strong handedness" (SH: EI absolute value between {pipe}81{pipe} and {pipe}100{pipe}) or "weak-handedness" (WH: EI value between -80 and +80). The nominal logistic regression did not show an FS effect, but a nearly significant interaction between illness and FS (p =.07). There were fewer participants without FS presenting SH among patients (99/151: 65.6%) than among controls (134/164: 81.7%, p =.001). In contrast, the number of participants with FS presenting SH was similar between controls (68%) and patients (75%, p =.57). The presence of left-handed relatives (FS +) tended to reduce manual lateralisation, but only in controls. This supports the notion that reduced manual lateralisation in schizophrenia is related to the illness rather than to familial left-handedness.
AB - The population with schizophrenia is characterised by a leftward shift in handedness-sinistrality. However, findings are inconsistent in chronic patients, and familial sinistrality (FS), defined as the presence of left-handed close relatives, might contribute to the discrepancies. Therefore the aim of this study was to investigate the strength of manual lateralisation in patients with first episode schizophrenia, taking into account familial sinistrality. The Edinburgh Inventory (EI) allowed us to categorise 179 patients from the EUFEST study and 189 controls presenting "strong handedness" (SH: EI absolute value between {pipe}81{pipe} and {pipe}100{pipe}) or "weak-handedness" (WH: EI value between -80 and +80). The nominal logistic regression did not show an FS effect, but a nearly significant interaction between illness and FS (p =.07). There were fewer participants without FS presenting SH among patients (99/151: 65.6%) than among controls (134/164: 81.7%, p =.001). In contrast, the number of participants with FS presenting SH was similar between controls (68%) and patients (75%, p =.57). The presence of left-handed relatives (FS +) tended to reduce manual lateralisation, but only in controls. This supports the notion that reduced manual lateralisation in schizophrenia is related to the illness rather than to familial left-handedness.
KW - First psychotic episode
KW - Handedness
KW - Laterality
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84858390078&partnerID=8YFLogxK
U2 - 10.1080/1357650X.2011.558510
DO - 10.1080/1357650X.2011.558510
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AN - SCOPUS:84858390078
VL - 17
SP - 217
EP - 224
JO - Laterality
JF - Laterality
SN - 1357-650X
IS - 2
ER -