Familial pemphigus vulgaris

Varda Katzenelson Weissman, Michael David, Rina Zamir, Juan Mellibovsky, Carlos Idises, Miriam Sandbank

Research output: Contribution to journalArticlepeer-review

Abstract

Familial pemphigus vulgaris was found in a Jewish woman and her son who developed the disease within a period of 18 months from one another. HLA typing was performed in the mother and son as well as in the unaffected father and sister. Examination of the HLA antigens in this family indicates that there may be different variants of DR4, DQw3and that one of them carried by the mother and son as part of the haplotype A30, B18. DR4, DQw3 is associated with pemphigus vulgaris. Our findings are in favor of the concept that particular polymorphic residues of class II major histocompatibility molecules are correlated with disease susceptibility.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalDermatology
Volume181
Issue number1
DOIs
StatePublished - 1990

Keywords

  • DQw3
  • Familial pemphigus vulgaris
  • HLA DR4

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