Familial mediterranean fever: Clinical, molecular and management advancements

Merav Lidar*, A. Livneh

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Familial Mediterranean fever (FMF), the most frequent of the periodic fever syndromes, is an autosomal recessive disease, predominantly affecting people of Mediterranean descent. The disease is caused by mutations in the MEFV gene, encoding the pyrin protein thought to be associated with the interleukin-I related inflammation cascade. The condition manifests as attacks of serositis, commonly involving the abdomen, chest or joints, typically accompanied by fever and elevated acute phase reactants. Attacks subside spontaneously within one to three days, without residue. Continuous treatment with colchicine, at a daily dose of 1 to 2 mg, reduces attack frequency, duration and intensity in the majority of patients, and also prevents the development of secondary amyloidosis, the most dreaded complication of the disease. In this communication we review the current state of the art in the diagnosis and care of FMF patients, starting with the presentation of a typical case.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalNetherlands Journal of Medicine
Issue number9
StatePublished - Oct 2007


  • Diagnosis
  • Familial Mediterranean fever
  • Treatment


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