Familial mediterranean fever and hypercoagulability

Oshrat E. Tayer-Shifman, Eldad Ben-Chetrit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. As such, FMF is a prototype of autoinflammatory diseases where genetic changes lead to acute inflammatory episodes. Systemic inflammation - in general - may increase procoagulant factors, and decrease natural anticoagulants and fibrinolytic activity. Therefore, it is anticipated to see more thrombotic events among FMF patients compared with healthy subjects. However, reviewing the current available literature and based upon our personal experience, thrombotic events related purely to FMF are very rare. Possible explanation for this discrepancy is that along with the procoagulant activity during FMF acute attacks, anticoagulant and fibrinolytic changes are also taking place. Colchicine which is the treatment of choice in FMF may also play a role in reducing inflammation thereby decreasing hypercoagulability.

Original languageEnglish
Article numbere2011017
JournalMediterranean Journal of Hematology and Infectious Diseases
Issue number1
StatePublished - 2011
Externally publishedYes


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